Yeah, the vast majority of my internal servers and containers are IPv6-only with only the public facing bits (haproxy and the like) also getting IPv4 for client connections.
We’re also careful that things like image mirrors are either dual-stack themselves or that our dispatcher checks what protocol the client used to reach us and then not redirect to a server which doesn’t support that protocol. This then lets us run IPv6-only or IPv4-only image mirrors just fine.